Molecular Mechanisms of Primary Aldosteronism

An update on novel mechanisms of primary aldosteronism.

Primary aldosteronism (PA) is the most common and curable form of secondary hypertension. It is caused in the majority of cases by either unilateral aldosterone overproduction due to an aldosterone-producing adenoma (APA) or by bilateral adrenal hyperplasia. Recent advances in genome technology have allowed researchers to unravel part of the genetic abnormalities underlying the development of A...

[Primary aldosteronism].

Franco Mantero, Gian Paolo Rossi, Enrico Agabiti Rosei Endocrine Unit, Department of Medical and Surgical Sciences, University of Padua, Italy Internal Medicine 4, Department of Clinical and Experimental Medicine, University of Padua, Italy Clinica Medica, Department of Medical and Surgical Sciences, University of Brescia, Italy European Society of Hypertension Scientific Newsletter: Update on ...

Patients With Primary Aldosteronism

To evaluate the difference in myocardial damage between primary aldosteronism and untreated essential hypertension, we performed thallium-201 myocardial single-photon emission computed tomography in 10 patients with primary aldosteronism and 10 patients with essential hypertension who were matched for age, sex, blood pressure, and the severity of left ventricular hypertrophy for primary aldoste...

Primary aldosteronism in pregnancy.

Aldosteronism is a rare complication of pregnancy. We report a case of a 26-year-old woman who became pregnant soon after a diagnosis of primary aldosteronism due to left adrenal adenoma was made. Only oral potassium supplementation was required in addition to routine prenatal care until 36 weeks' gestation. Subsequently, antihypertensive medication was needed to control elevated blood pressure...

Identifying primary aldosteronism